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CPAP and Glucose Metabolism in Non-Diabetic OSA Subjects
The purpose of the current study is to investigate whether alleviation of OSA by CPAP positively impacts glucose metabolism in non-diabetic patients.
Study details:
Glucose metabolism in patients newly diagnosed with moderate-severe OSA and without diabetes will be monitored for two weeks prior to commencement of CPAP using a CGM. They will consume a 75g oral glucose drink fasted on waking twice during the two-week monitoring period, having consumed a standardised meal the evening prior. After establishing CPAP use for at least four weeks they will undergo the same protocol as for the observation period prior to commencing CPAP.
Glucose metabolism will be monitored using an interstitial (skin based) glucose monitor.
Eligibility criteria
Researchers look for people who fit a certain description, called eligibility criteria. See if you qualify.
Inclusion criteria
Exclusion criteria
Eligibility
Age eligible for study : 18 and older
Healthy volunteers accepted : Yes
Gender eligible for study: All
Things to know
Study dates
Study start: 2024-07-01
Primary completion: 2025-02-28
Study completion finish: 2025-02-28
Study type
TREATMENT
Phase
NA
Trial ID
NCT05335083
Intervention or treatment
DEVICE: CPAP
Conditions
- • Obstructive Sleep Apnea
- • Pre-diabetes
Find a site
Closest Location:
Woolcock Institute of Medical Research
Research sites nearby
Select from list below to view details:
Woolcock Institute of Medical Research
Macquarie Park, New South Wales, Australia
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Participant Group/Arm | Intervention/Treatment |
---|---|
NO_INTERVENTION: CPAP off condition
| Not specified |
EXPERIMENTAL: CPAP on condition
| DEVICE: CPAP
|
What is the study measuring?
Primary outcome
Primary Outcome Measure | Primary Outcome Description | Primary Outcome Time Frame |
---|---|---|
Mean 24 hour glucose difference between the CPAP on and CPAP off conditions | Average 24 hour glucose difference between CPAP on and CPAP off conditions | 2 weeks |
Secondary outcome
Secondary Outcome Measure | Secondary Outcome Description | Secondary Outcome Time Frame |
---|---|---|
Mean daytime glucose difference between the CPAP on and CPAP off conditions | Mean Daytime (6:00 AM - 10:00 PM) glucose difference between the CPAP on and CPAP off conditions as measured by the FreeStyle Libre Pro sensor during the 2-week intervention periods. | 2 weeks |
Mean night time glucose | Mean Night-time (10:00 PM - 6:00 AM) glucose difference between the CPAP on and CPAP off conditions as measured by the FreeStyle Libre Pro sensor during the 2-week intervention periods. | 2 weeks |
Glucose tolerance | Difference in glucose tolerance as measured by peak 2-hour post 75g glucose load administered twice during each two-week observation period using a CGM | 2 weeks |
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