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Effects of Time of Day and Nut Intake on Cognitive Performance

RECRUITING

This is a 2 x 2-factor crossover design study to investigate the effects of time of day and nuts on post-meal cognitive performance.

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Study details:

In this trial, eligible participants will receive isocaloric meals with or without nuts at lunchtime and dinner time. Cognitive performance will be performed before and 90 min after the meals.

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Eligibility criteria

Researchers look for people who fit a certain description, called eligibility criteria. See if you qualify.

Inclusion criteria

  • Non-shift workers
  • 18-55 years
  • BMI between 18.5 and 27 kg/m2
  • Non-smokers
  • Without chronic illnesses
  • Exclusion criteria

  • Allergy to nuts
  • BMI<18.5 or >27 kg/m2
  • Presence of dementia or psychiatric disease (depression, Parkinson's disease, schizophrenia)
  • Presence of diabetes, serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery, cardiovascular disease
  • Presence of any sleep disorders
  • Taking anti-diabetic or lipid-lowering medication
  • Do not speak English
  • Pregnant or planning on becoming pregnant
  • Breastfeeding
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    Eligibility

    Age eligible for study : 18 and older

    Healthy volunteers accepted : Yes

    Gender eligible for study: All

    Things to know

    Study dates

    Study start: 2024-04-08

    Primary completion: 2025-02-28

    Study completion finish: 2025-06-30

    study type

    Study type

    PREVENTION

    phase

    Phase

      NA

    trial

    Trial ID

    NCT06343142

    Intervention or treatment

    OTHER: Nuts

    OTHER: Nut-free meal

    Conditions

    • Cognitive Performance

    Find a site

    Closest Location:

    Department of Nutrition, Dietetics and Food - Monash University

    Research sites nearby

    Select from list below to view details:

    • Department of Nutrition, Dietetics and Food - Monash University

      Notting Hill, Victoria, Australia

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    Study Plan

    This section provides details of the study plan, including how the study is designed and what the study is measuring.

    How is the study designed?

    Participant Group/ArmIntervention/Treatment
    PLACEBO_COMPARATOR: Lunch nut-free meal
    • Participants will receive an isocaloric meal without nuts at lunchtime.
    OTHER: Nut-free meal
    • Isocaloric meal without nuts
    EXPERIMENTAL: Lunch nut meal
    • Participants will receive an isocaloric meal with nuts at lunchtime.
    OTHER: Nuts
    • Isocaloric meal with nuts
    PLACEBO_COMPARATOR: Dinner nut-free meal
    • Participants will receive an isocaloric meal without nuts at dinner.
    OTHER: Nut-free meal
    • Isocaloric meal without nuts
    EXPERIMENTAL: Dinner nut meal
    • Participants will receive an isocaloric meal with nuts at dinner.
    OTHER: Nuts
    • Isocaloric meal with nuts

    What is the study measuring?

    Primary outcome

    Primary Outcome MeasurePrimary Outcome DescriptionPrimary Outcome Time Frame
    N-back task - accuracyDifference in the total accuracybefore meal x 90 min post-meal
    N-back task - matched responsesDifference in the % matched responsesbefore meal x 90 min post-meal
    N-back task - false alarmDifference in the % false alarmbefore meal x 90 min post-meal
    N-back task - reaction timeDifference in the reaction time for correct matched responsesbefore meal x 90 min post-meal
    Stroop test - congruentDifference in the reaction time for congruentbefore meal x 90 min post-meal
    Stroop test - incongruentDifference in the reaction time for incongruentbefore meal x 90 min post-meal
    Stroop test - interferenceDifference in stroop interference (incongruent - congruent response time)before meal x 90 min post-meal

    Secondary outcome

    Secondary Outcome MeasureSecondary Outcome DescriptionSecondary Outcome Time Frame
    Multitasking - pure blocksDifference in the reaction time for pure blocksbefore meal x 90 min post-meal
    Multitasking - mixed blocksDifference in the reaction time for mixed blocksbefore meal x 90 min post-meal
    Multitasking - mixing costDifference in mixing cost (mixed - pure reaction time)before meal x 90 min post-meal
    Satiety - hungerDifference in postprandial hungerHunger will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).
    Satiety - fullnessDifference in postprandial fullnessFullness will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).
    Satiety - satisfactionDifference in postprandial satisfactionSatisfaction will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).
    Satiety - eating capacityDifference in postprandial eating capacity,Eating capacity will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).
    Satiety indexDifference in postprandial satiety index, calculated using the mean of the four satiety questions, where "hunger" and "eating capacity" will be scored in an inverse way than "fullness" and "satisfaction".Satiety index will be assessed before the meal and 4 times after the meal (15, 30, 60 and 90 mins).

    Frequently Asked Questions

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    References

    Clinical Trials Gov: Effects of Time of Day and Nut Intake on Cognitive Performance

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