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Effects of Time of Day and Nut Intake on Cognitive Performance

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This is a 2 x 2-factor crossover design study to investigate the effects of time of day and nuts on post-meal cognitive performance.

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Study details:

In this trial, eligible participants will receive isocaloric meals with or without nuts at lunchtime and dinner time. Cognitive performance will be performed before and 90 min after the meals.

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Eligibility criteria

Researchers look for people who fit a certain description, called eligibility criteria. See if you qualify.

Inclusion criteria

Non-shift workers

18-55 years

BMI between 18.5 and 27 kg/m2

Non-smokers

Without chronic illnesses

Exclusion criteria

Allergy to nuts

BMI<18.5 or >27 kg/m2

Presence of dementia or psychiatric disease (depression, Parkinson's disease, schizophrenia)

Presence of diabetes, serious health conditions that may affect participation e.g. liver or thyroid dysfunction, recent major surgery, cardiovascular disease

Presence of any sleep disorders

Taking anti-diabetic or lipid-lowering medication

Do not speak English

Pregnant or planning on becoming pregnant

Breastfeeding

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Eligibility

Age eligible for study : 18 and older

Healthy volunteers accepted : Yes

Gender eligible for study: All

Things to know

Study dates

Study start: 2024-04-08

Primary completion: 2025-02-28

Study completion finish: 2025-06-30

Study type

PREVENTION

Phase

Trial ID

NCT06343142

Intervention or treatment

OTHER: Nuts

OTHER: Nut-free meal

Conditions

• Cognitive Performance

Condition: Cognitive Performance
OTHER: Nuts and other drugs
Notting Hill, Victoria, Australia
Sponsor: Monash University

You may be eligible to participate in this trial based on your search. Check eligibility by answering some questions.

Are you running this trial? If you're a clinic or sponsor, you can claim this study. Claim or learn more.

Find a site

Closest Location:

Department of Nutrition, Dietetics and Food - Monash University

Research sites nearby

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Department of Nutrition, Dietetics and Food - Monash University
Notting Hill, Victoria, Australia

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Participant Group/Arm	Intervention/Treatment
PLACEBO_COMPARATOR: Lunch nut-free meal Participants will receive an isocaloric meal without nuts at lunchtime.	OTHER: Nut-free meal Isocaloric meal without nuts
EXPERIMENTAL: Lunch nut meal Participants will receive an isocaloric meal with nuts at lunchtime.	OTHER: Nuts Isocaloric meal with nuts
PLACEBO_COMPARATOR: Dinner nut-free meal Participants will receive an isocaloric meal without nuts at dinner.	OTHER: Nut-free meal Isocaloric meal without nuts
EXPERIMENTAL: Dinner nut meal Participants will receive an isocaloric meal with nuts at dinner.	OTHER: Nuts Isocaloric meal with nuts

What is the study measuring?

Primary outcome

Primary Outcome Measure	Primary Outcome Description	Primary Outcome Time Frame
N-back task - accuracy	Difference in the total accuracy	before meal x 90 min post-meal
N-back task - matched responses	Difference in the % matched responses	before meal x 90 min post-meal
N-back task - false alarm	Difference in the % false alarm	before meal x 90 min post-meal
N-back task - reaction time	Difference in the reaction time for correct matched responses	before meal x 90 min post-meal
Stroop test - congruent	Difference in the reaction time for congruent	before meal x 90 min post-meal
Stroop test - incongruent	Difference in the reaction time for incongruent	before meal x 90 min post-meal
Stroop test - interference	Difference in stroop interference (incongruent - congruent response time)	before meal x 90 min post-meal

Secondary outcome

Secondary Outcome Measure	Secondary Outcome Description	Secondary Outcome Time Frame
Multitasking - pure blocks	Difference in the reaction time for pure blocks	before meal x 90 min post-meal
Multitasking - mixed blocks	Difference in the reaction time for mixed blocks	before meal x 90 min post-meal
Multitasking - mixing cost	Difference in mixing cost (mixed - pure reaction time)	before meal x 90 min post-meal
Satiety - hunger	Difference in postprandial hunger	Hunger will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).
Satiety - fullness	Difference in postprandial fullness	Fullness will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).
Satiety - satisfaction	Difference in postprandial satisfaction	Satisfaction will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).
Satiety - eating capacity	Difference in postprandial eating capacity,	Eating capacity will be assessed with a visual analog scale before the meal and 4 times after the meal (15, 30, 60 and 90 mins).
Satiety index	Difference in postprandial satiety index, calculated using the mean of the four satiety questions, where "hunger" and "eating capacity" will be scored in an inverse way than "fullness" and "satisfaction".	Satiety index will be assessed before the meal and 4 times after the meal (15, 30, 60 and 90 mins).

Frequently Asked Questions

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References

Clinical Trials Gov: Effects of Time of Day and Nut Intake on Cognitive Performance